IgG4 after 5X shots (min 2X mRNA) - 1st direct evidence of immune refocusing - good or bad? (Ep скачать в хорошем качестве

IgG4 after 5X shots (min 2X mRNA) - 1st direct evidence of immune refocusing - good or bad? (Ep

Further evidence of IgG4 antibodies formation in mRNA vaccinated with new unwelcome twists introduced to the story. The study shows that boosting with mRNA vaccines appears desirable because, within a month of boosting, resulting antibodies were able to neutralize more viruses and against more variants, including the latest variants. Both of these appear very desirable outcomes of mRNA shots. However, two more aspects are also observed. It appears that all participants produced more IgG4 post mRNA XBB1.15 booster, including those that were infected prior to vaccination. Previously data suggested that such infection prior to vaccination offered protection from IgG4 antibody development. The study also looked at memory B cells targets and showed that mRNA boosting increased antibodies targeting other areas of the spike protein away from the receptor binding domain of the spike protein. This demonstrates that immune refocusing is taking place post mRNA boosting, meaning, the immune system is trained to target other areas of the spike protein more frequently than before. This is also 5th IgG4 study analyzed showing increased neutralization of more variants after mRNA boosting along with an increase in IgG4 antibody levels. This points to a potential autoimmune risk if the new areas of spike protein that are being targeted are similar to human proteins. What we cover: *First direct proof that IgG4 antibodies participate in immune refocusing *The study suggests that protection from IgG4 production in mRNA vaccinated can disappear *Boosters appear desirable because they appear to increase the neutralization of virus and against more variants *However, this is achieved by shifting antibodies from the binding domain to other areas of the spike protein *Study shows cross-neutralization suggesting that very common areas of spike protein are targeted between the variants *What this shift means clinically is not known *If against conserved areas of virus = risk that these areas are also conserved in human and why not typically targeted by the immune system *Targeting areas of the virus that mimic human sequence could induce autoimmune conditions Location: Stoney Creek Provincial Recreation Area, Alberta Described content: https://www.biorxiv.org/content/10.11... __________________________________________________________________ Dr. Raszek Credentials: https://merogenomics.ca/en/about/ ____________________________________________________________________ Please stay in touch with us on other social media channels: Twitter:   / merogenomics   Facebook:   / merogenomics   Blog: https://merogenomics.ca/blog/ Previously Microsoft was providing inappropriate warning about our newsletter sign up. If this happens again, there is an alternative option. Original Newsletter sign up (safe!): https://share.ebforms.com/53718243485... Alternate Newsletter sign up: http://eepurl.com/hesNGf Instagram:   / merogenomics   Patreon:   / merogenomics