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What if the #1 reason you're aging faster is a mistake hidden deep within your blood? Over time, our bloodstream accumulates a "sludge" of inflammatory molecules, toxins, and damaged proteins that accelerate aging and drive chronic disease. But what if you could perform an "oil change" on your body to clean it all out? On this episode of The Doctor's Farmacy, Dr. Mark Hyman sits down with Mayo-trained surgeon Dr. Darshan Shah to discuss a breakthrough blood therapy that is changing the game for longevity and health optimization. After reversing his own five chronic diseases—including diabetes and uncontrolled hypertension—Dr. Shah has dedicated his career to the new science of creating health, not just managing sickness. In this conversation, you will learn: How inflammatory biomarkers in your blood are a root cause of "inflammaging" and chronic disease. What plasmapheresis is and how this blood cleaning therapy removes toxins, damaged proteins, and senescent "zombie cells". The incredible research showing plasmapheresis can improve symptoms of Long COVID and even slow Alzheimer's disease progression by up to 61%. How Dr. Hyman lowered his biological age by four years using therapies like this. Why plasmapheresis is a promising treatment for high Lp(a), a stubborn genetic risk factor for heart disease. Other longevity therapies like hyperbaric oxygen, sauna, and cold plunge that use hormesis to make your cells stronger and more resilient. What is the one longevity therapy you're most excited to try? Let us know in the comments below! 👇 If you enjoyed this video, be sure to subscribe for more conversations on the future of health. Learn more about Dr. Darshan Shah and the therapies discussed at Next Health. #ReverseAging #Longevity #Plasmapheresis #DrMarkHyman #Inflammation Get my FREE guide 3 Steps to Reverse Aging when you sign up for my weekly health picks 👉 https://bit.ly/IncreaseHealthspan View Show Notes From This Episode: https://bit.ly/41KTaF8 @DarshanShahMD This episode is brought to you by BonCharge, Timeline, Big Bold Health, and Sunlighten. Order BON CHARGE’s Max Red Light Therapy device today and get 15% off. Visit https://BonCharge.com and use code DRMARK for 15% off. Get 33% off your order of Mitopure while supplies last. Go to https://Timeline.com/HYMAN33 today. Your future self will thank you! Try Big Bold Health's HTB Rejuvenate and get 25% off by going to https://BigBoldHealth.Com and use code DRMARK25 at checkout. Visit https://Sunlighten.com and save up to $600 on your purchase with code HYMAN. Experts explain how removing inflammatory biomarkers from the blood reduces *inflammation in the body**, helping organs thrive. By creating a healthy environment, the body can avoid **chronic disease* and promote *healthy eating**. Learn the secrets to better **health* through **functional medicine**. (0:00) Introduction and discussion on inflammation reduction (1:07) Dr. Darshan Shah's journey from surgery to longevity medicine (5:08) Dr. Shah's personal health transformation (7:28) Vision of Next Health and innovative aging therapies (14:14) Plasmapheresis: Explanation, benefits, and patient experiences (28:22) The role of inflammation in aging and chronic diseases (30:30) Plasmapheresis research in Alzheimer's and cardiovascular health (36:33) Frequency and biomarker tracking for plasmapheresis (41:19) Future accessibility of plasmapheresis (43:01) Albumin's role in health and longevity (45:50) Longevity therapies: Research, costs, and access challenges (49:35) Lifestyle interventions and other therapies for chronic disease (54:16) Hormesis and affordable longevity interventions (59:47) Personalized medicine and the future of healthcare systems (1:04:35) Expanding access to longevity therapies (1:04:48) Closing remarks and appreciation