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Dr. Navdeep Tangri, who had developed and validated the Kidney Failure Risk Equation (KFRE) in Canada, explains why both general practicians and nephrologists should use the KFRE regularly and predict the risk of chronic kidney disease (CKD) progression in their individual patients. Moreover, he discusses whether recent changes in glomerular filtration rate (GFR) estimation and the advent of novel renoprotective medication such as SGLT-2 inhibitors and finerenone will affect the KRFE's performance. Articles discussed: Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR below 45 mL/min/1.73 m2) Farrington et al., Nephrology Dialysis Transplantation 2016 https://www.era-online.org/en/erbp/gu... The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Shlipak et al., Kidney International 2021 https://www.kidney-international.org/... Validation of the Kidney Failure Risk Equation in Kidney Transplant Recipients Tangri et al., Canadian Journal of Kidney Health and Disease 2020 https://journals.sagepub.com/doi/10.1... Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial Wheeler et al., The Lancet Diabetes & Endocrinology 2021 https://www.sciencedirect.com/science... Effect of dapagliflozin on the rate of decline in kidney function in patients with chronic kidney disease with and without type 2 diabetes: a prespecified analysis from the DAPA-CKD trial Heerspink et al., The Lancet Diabetes & Endocrinology 2021 https://www.sciencedirect.com/science... Use of the Kidney Failure Risk Equation to Determine the Risk of Progression to End-stage Renal Disease in Children With Chronic Kidney Disease Winnicki et al., JAMA Pediatrics 2018 https://jamanetwork.com/journals/jama... National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race Duggal et al., cJASN 2021 https://jasn.asnjournals.org/content/... The Promise of Tubule Biomarkers in Kidney Disease: A Review Ix et al., AJKD 2021 https://www.ajkd.org/article/S0272-63... Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate Grams et al., Kidney Int 2018 https://www.kidney-international.org/...