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In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez, is joined by Drs. Alex Melamed and René Pareja to discuss De-escalation in Gynecologic Oncology. Alex Melamed, MD, MPH, is a gynecologic oncologist and clinical outcomes researcher in the Department of Obstetrics and Gynecology at Mass General Hospital and an Associate Professor at Harvard Medical School. He co-directs the Inference Lab in MGH's Vincent Department of Obstetrics and Gynecology. Dr. Melamed's research focuses on applying methods that provide meaningful insights from observational data. In particular, his work explores how focusing on temporal and spatial variation in clinical practice can help to uncover how health care affects patient outcomes. Some of his research focuses on increasing understanding of how surgical care affects the lives of cancer patients. Dr. Melamed is an associate editor of the International Journal of Gynecologic Cancer. Dr. René Pareja is a Gynecologist and Obstetrician, graduated from Universidad Pontificia Bolivariana in Medellín, Colombia in 2000; he finished his training in Gynecologic Oncology in 2003, from Pontificia Universidad Javeriana and Instituto Nacional de Cancerología in Bogotá, Colombia. He is a minimally invasive surgeon, graduated from Corporación de Estudios de la Salud (CES) in 2013. He currently works at Astorga Oncology Clinic in Medellín and at National Cancer Institute in Bogotá, Colombia. Dr. Pareja serves as a reviewer for more than 20 journals. He has authored or co-authored nine book chapters and more than fifty publications in peer-reviewed journals. Currently he is an Associate Editor of the International Journal of Gynaecological Cancer and is a Council member of the International Gynecological Cancer Society Council. He also serves as an international mentor for the Hospital General San Juan de Dios in Guatemala through the IGCS Global Curriculum & Mentorship Program.Some of his research has influenced how gynecologic oncologists treat cancer and has been published in important medical journals, like the New England Journal of Medicine, JAMA, and Journal of Clinical Oncology.