Osteobites | Deciphering the impact of STING agonists on the tumor microenvironment in osteosarcoma скачать в хорошем качестве

Osteobites | Deciphering the impact of STING agonists on the tumor microenvironment in osteosarcoma

Brian Ladle, MD, PhD, Assistant Professor of Oncology and Pediatrics at The Johns Hopkins University School of Medicine, joins us on OsteoBites to discuss deciphering the impact of STING agonists on the tumor microenvironment in osteosarcoma. We have learned that more engagement of the immune system and osteosarcoma results in better outcomes - even when patients are given standard chemotherapy. We have found that drugs that activate the STING pathway in osteosarcoma tumors result in greater immune cell invasion into the tumors. This corresponds with improved outcomes when combined with chemotherapy and other immunotherapies. Dr. Ladle discusses these findings and what steps we are taking to bring this closer to clinical trials for osteosarcoma patients. You're not alone. We're here for you. 💙 --- What are OsteoBites? OsteoBites are weekly webinars and podcasts presented by MIB Agents, an organization dedicated to Making It Better for children with osteosarcoma. We offer education, support, and advocacy for families facing this challenging disease. Learn more about our mission and programs at https://www.mibagents.org --- Want to support our mission? Donate here: https://give-usa.keela.co/embed/YAipu... Factor 2025 Registration - https://www.mibagents.org/research/fa... Bing Osteosarcoma Auction - https://tockify.com/mibagents/detail/... Instagram -   / mib.agents   X - https://x.com/AgentsMIB Facebook -   / mibagents   Stay updated with the latest news and events: https://www.mibagents.org/how-to-help... --- 0:00 - Introduction & Announcements 2:06 - The Osteosarcoma Plateau 4:42 - Why Immunotherapy? 11:53 - The STING Pathway: A Deeper Dive 16:34 - Canine Clinical Trials 29:07 - Mouse Models & The "Golden Ticket" Experiment 45:47 - Conclusions & Future Directions 51:48 - Q&A & Closing #medicaleducation #osteosarcoma #cancerresearch #cancertreatment