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In this episode, an international expert panel shares their thoughts on key considerations for incorporating long-acting cabotegravir as an additional HIV pre-exposure prophylaxis option for appropriate individuals at high risk of acquiring HIV infection. Topics include anticipated patient interest in this new paradigm, the role of the oral lead-in phase, new guideline recommendations for monitoring during PrEP, patient care and follow-up after PrEP discontinuation, and remaining unanswered questions. Other episodes in this 4-part series cover additional aspects of long-acting antiretrovirals for HIV treatment and prevention, including key steps for switching patients to long-acting injectable cabotegravir plus rilpivirine for HIV treatment, such as selecting the most appropriate patients, introducing patients to the long-acting option, and preparing patients for what to expect from long-acting treatment in terms of efficacy, visit timing, and the injection experience; key considerations at the operational level for incorporating long-acting injectable ART into the HIV treatment armamentarium; and what is still needed in long-acting HIV care to further address patient needs and inequities across subgroups. Presenters: Babafemi Taiwo, MBBS Gene Stollerman Professor of Medicine Chief, Division of Infectious Diseases Northwestern University Feinberg School of Medicine Chicago, Illinois Yvonne Gilleece, MB BCh, BAO Honorary Clinical Professor in HIV Medicine and Sexual Health Department of Global Health & HIV Brighton & Sussex Medical School Consultant in HIV Medicine and Sexual Health HIV Department University Hospitals Sussex NHS Foundation Trust Brighton, United Kingdom Cristina Mussini, MD Head of Department of Infectious Diseases and Tropical Medicine Full Professor of Infectious Diseases Infectious Diseases Clinics, University Hospital University of Modena and Reggio Emilia Modena, Italy Darrell H. S. Tan, MD, FRCPC, PhD Associate Professor Division of Infectious Diseases University of Toronto Clinician-Scientist Division of Infectious Diseases St. Michael's Hospital Toronto, Canada Content based on an online CME/CE program supported by an independent educational grant from ViiV Healthcare. Link to full program: https://bit.ly/3P3uPBc Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com (https://pcm.adswizz.com) for information about our collection and use of personal data for advertising.