AIRRC5 - LIBRA-seq: Linking antibody sequence to antigen specificity (I. Georgiev) скачать в хорошем качестве

AIRRC5 - LIBRA-seq: Linking antibody sequence to antigen specificity (I. Georgiev)

Session from the "AIRR Community Meeting V – Zooming in to the AIRR Community!" (December 8-10, 2020) The meeting covers progress reports from the AIRR-C Working Groups & Sub-committees, two scientific sessions (including four short talks chosen from the posters), two interactive poster sessions and four live software tool demonstrations. https://www.antibodysociety.org/the-a... Basic Science Session - Moderated by Jason Vander Heiden (Scientist, Genentech) LIBRA-seq: Linking antibody sequence to antigen specificity Ivelin Georgiev Associate Professor, Vanderbilt University Medical Center • LIBRA-seq is a technology for high-throughput mapping of BCR sequence to antigen specificity through sequencing. • LIBRA-seq was initially validated on samples from two HIV-infected subjects, identifying both HIV- and influenza-specific B cells, predicting antigen reactivity for thousands of single B cells, and discovering a previously unknown broadly neutralizing HIV antibody. • LIBRA-seq will be of utility for antibody discovery, vaccine evaluation, and antibody-antigen specificity characterization.