AIRR C Seminar Series, March 27, 2025 Frederick Matsen, Fred Hutch, United States скачать в хорошем качестве

AIRR C Seminar Series, March 27, 2025 Frederick Matsen, Fred Hutch, United States

Talk title: Inviting Darwin into antibody foundation models Established Career Speaker: Frederick Matsen, Fred Hutch, USA Talk Abstract Eric Matson's talk challenges the idea that large AI models alone can solve biological problems. He argues that incorporating fundamental biology into machine learning models improves accuracy, efficiency, and interpretability. Focusing on antibodies, he explains how they evolve through VDJ recombination and selection, creating diverse immune responses. He critiques current antibody language models, showing that they perform well on germline residues but fail on mutated sites. He highlights efforts to refine these models, emphasizing the need to integrate biological principles for better predictions. Speaker Bio Frederick Matsen is a professor at Fred Hutch and an expert in computational biology, developing algorithms to analyze biological data. His research focuses on sequencing-based studies of viruses, immune cells, and complex microbial communities. He also works on phylogenetics, improving methods for constructing evolutionary trees. In addition to developing open-source computational tools, he contributes to large-scale collaborative projects in the field. Matsen holds a PhD in Mathematics from Harvard University and is a Howard Hughes Medical Institute Investigator. AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...