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As the NYSORA YouTube channel grows to 50,000 subscribers, we start a series of videos on Exparel®, liposomal bupivacaine, based on viewers’ requests. In this (unsolicited) video, Dr. Hadzic discusses some fascinating pharmacologic developments and clinical experiences with this formulation of Bupivacaine. He then argues that the regional anesthesia community is failing to conduct the much-needed relevant clinical studies that inform the practitioners of regional anesthesia of the most effective ways of using this formulation of bupivacaine. “Obsessed with the development of new ultrasound-guided injection techniques, we have neglected the most significant development in local anesthetics in twenty years - the liposomal bupivacaine”. In this video, Dr. Hadzic simplifies the studies that lead to the approval of Exparel® for the Interscalene brachial plexus block and discusses the paradox of non-approval of Exparel® for other nerve block applications in the USA. In contrast, in Europe, the formulation was approved for both Interscalene brachial plexus blocks and femoral nerve blocks for the treatment of postoperative pain in adults by the European Medicines Agency, the equivalent of the FDA in Europe. 🖥 Start your 7-day free trial on the NYSORA LMS today and see why it is the go-to resource to master Regional Anesthesia at https://bit.ly/3rmvkwH 📱 Download the NYSORA Nerve Blocks app iOS: https://apple.co/2WUqoi7 Android: https://bit.ly/NYSORAMApp Where else to find us: Web- http://www.nysora.com Twitter- / nysora Instagram- / nysora_community Facebook- / nysora TikTok- / nysora_community --------------------------------------------------------- #nysora #regionalanesthesia #anesthesia Disclaimer: Medicine is an ever-changing science. As new research and clinical experience broaden, changes in treatment and drug therapy are required. The authors and publisher of have checked with sources believed to be reliable in efforts to provide accurate information within the available or accepted standards of care. However, given the possibility of human error or changes in medical practice, neither the authors nor the publisher, nor any other party involved in the preparation of this platform warrants that the information contained herein is in every aspect accurate or complete, and they disclaim all responsibility for any errors or omissions for the results obtained from the use of the information contained in this work. Readers are advised to confirm the information contained herein with other sources. For example, readers are advised to check the product information of each drug mentioned, and that any information contained on NYSORA Youtube channel is accurate.