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𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : / clinical.learning Thalidomide: Pharmacology Videos ---------------------------------------------------------- Thalidomide is a drug with a controversial history, originally marketed in the 1950s and 1960s as a sedative and treatment for morning sickness in pregnant women, but it was withdrawn due to its severe teratogenic effects, causing birth defects 🍼🍼. Despite this tragic history, thalidomide has found renewed use in the treatment of various conditions, particularly in hematologic malignancies like multiple myeloma and certain skin conditions like erythema nodosum leprosum, a complication of leprosy 🩸💉. Thalidomide works by modulating the immune system, inhibiting angiogenesis (the formation of new blood vessels), and having anti-inflammatory and anti-tumor effects 🌿. It suppresses the production of pro-inflammatory cytokines like TNF-alpha, which plays a role in various inflammatory diseases 🌍. While it is now used under strict controls due to its teratogenicity, thalidomide's therapeutic potential in conditions like cancer and leprosy makes it a valuable drug when used cautiously 💊💉. However, due to its potential to cause birth defects, patients must adhere to strict contraception protocols when using it ⚠️. Thalidomide is a prime example of a drug that evolved from tragedy to therapeutic innovation 🌟. #Thalidomide #MultipleMyeloma #Leprosy #Hematology #Pharmacology #Teratogenicity #AntiInflammatory #CancerTreatment #Angiogenesis #MedicalHistory #Immunomodulation #USMLE #NEETPG #Pharmaceutics #DrugSafety #HealthCare #PharmaceuticalInnovation #MedicalScience 🧬🧪💊