Dextran Sulfate Sodium (DSS) Modeling of Murine Colitis скачать в хорошем качестве

Dextran Sulfate Sodium (DSS) Modeling of Murine Colitis

Reference: https://app.jove.com/v/1652/murine-co... Dextran Sulfate Sodium (DSS) is a commonly used chemical compound in the field of biomedical research for modeling murine colitis. Murine colitis refers to the inflammation of the colon in mice, which closely resembles human inflammatory bowel disease (IBD) such as ulcerative colitis. DSS is a sulfated polysaccharide that is derived from dextran, a glucose polymer. It is known to induce colitis-like symptoms in mice when administered orally or added to their drinking water. The mechanism of action of DSS involves damaging the intestinal epithelial barrier, leading to increased permeability and subsequent infiltration of immune cells into the colon. By inducing colitis in mice, researchers can study the pathogenesis, progression, and potential therapeutic interventions for human IBD. DSS-induced colitis in mice closely mimics the clinical and histopathological features of human ulcerative colitis, making it a valuable tool for studying the disease. The administration of DSS to mice results in various symptoms characteristic of colitis, including weight loss, diarrhea, rectal bleeding, and colon shortening. These symptoms can be monitored and quantified to assess the severity of colitis and evaluate the efficacy of potential treatments.