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The COVID-19 pandemic and other recent health emergencies revealed significant gaps in countries’ ability to prevent, prepare for, and respond to health threats. These crises showed that systems built on trust, data, and science are essential for effective action. National Public Health Agencies (NPHAs) play a critical role in strengthening emergency preparedness and response by translating insights and intelligence into effective, equitable action, while safeguarding population health, societal resilience, and economic stability. To strengthen collective preparedness for future emergencies, WHO, in collaboration with the International Association of National Public Health Institutes (IANPHI) and other partners, led a global consultative process with over 120 countries and organizations. The process aimed to define the essential capabilities NPHAs require to lead, coordinate, and sustain health emergency functions. The resulting Framework for Health Emergency Preparedness and Response Capabilities for NPHAs reflects the collective expertise of public health leaders worldwide and provides practical guidance to strengthen NPHAs and their role for emergency preparedness and response. Alongside the WHO guidance, this session will also showcase the IANPHI Framework for the Creation and Development of National Public Health Institutes (V2), which serves as the strategic roadmap for the structural and institutional design of these agencies. These two frameworks are intrinsically complementary. The IANPHI Framework establishes the institutional foundation by categorising the 12 Essential Public Health Functions into core, desirable, and optional national public health institute functions. The WHO Framework contributes the technical granularity necessary for effective health emergency management. Together, they align institutional development with specific emergency preparedness and response capabilities, offering a coherent and unified approach for strengthening NPHAs worldwide. This session will highlight both frameworks, featuring insights from NPHA leaders, global partners, and technical experts. Speakers will discuss how the frameworks can be adapted across diverse national and regional contexts and translated into coordinated, actionable, system-wide, and sustainable interventions to strengthen emergency preparedness and response at national, regional and global levels. The Speaker Series is co-hosted by the WHO Hub for Pandemic and Epidemic Intelligence and the Charité Center for Global Health. More info: https://pandemichub.who.int/news-room...