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This component of the Early Psychosis Learning Series explores the relation between clinical high-risk (CHR) for psychosis and common comorbid conditions, such as depression, anxiety, trauma, and substance use. It examines how these comorbidities influence symptom severity, diagnosis, and treatment approaches, highlighting the importance of comprehensive assessment and individualized care. Research findings and clinical considerations are discussed to improve understanding and intervention strategies. Component Learning Objectives: 1. Identify common comorbid conditions associated with clinical high-risk (CHR) for psychosis and be familiar with their prevalence based on research findings. 2. Differentiate between primary psychotic symptoms and symptoms influenced by comorbid conditions such as anxiety, depression, trauma, and substance use. 3. Explain how comorbid conditions impact symptom severity, functional outcomes, and treatment approaches in individuals at CHR for psychosis.