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Dr. Ebraheim’s educational animated video describes a patient case of Anterior Interosseous Nerve Injury. Normal: patient is able to perform the OK sign. Abnormal: patient cannot perform the OK sign. The anterior interosseous nerve branches from the median nerve of the brachial plexus. The anterior interosseous nerve innervates three muscles of the forearm: 1- Flexor pollicis longus 2- Flexor digitorum profundus (lateral half) 3- Pronator quadratus The integrity of the anterior interosseous nerve is tested by performing the OK or circle sign. Ask the patient to make the OK sign by touching the tips of the index finger and thumb together. The integrity of the anterior interosseous nerve allows flexion of the distal phalanx of the thumb and the index finger. when an anterior interosseous nerve injury is present, the patient will be unable to bring together the distal phalanx of the thumb and the index finger. will be unable to make the OK sign. Testing the integrity of the anterior interosseous nerve by touching together the middle finger and the distal phalanx of the thumb is not reliable. With injury to the nerve there will be a loss of motor function, however there will be no loss of sensory function. Unable to do OK sign. Loss of motor function. There will be aching in the anterior forearm. Treatment Usually observation with EMG testing Exploration and release if no improvement in 4-6 months. Differential diagnosis Unable to do the OK sign may also result from a high median nerve injury. The presence of sensory symptoms indicates a median nerve injury. The OK sign is different from the Froment's sign, which is performed to determine the presence of an ulnar nerve injury. When pinching a piece of paper between the thumb and the index finger, the thumb IP joint will flex if the adductor pollicis muscle is weak. With ulnar nerve injury, the adductor pollicis muscle is weak and the patient cannot adduct the thumb. The flexor pollicis longus muscle substitutes for this movement by flexing the thumb. Bending of the thumb when pinching the piece of paper is a sign of an ulnar nerve injury. Become a friend on facebook: / drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC