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Explore groundbreaking research on the complex relationship between cannabis and opioid addiction in this keynote presentation by Dr. Yasmin Hurd, Director of the Addiction Institute at Mount Sinai. Dr. Hurd examines the opioid crisis and investigates whether cannabis—particularly its key compounds, THC and CBD—could be part of the solution or contribute to the problem. Her research spans molecular neuroscience, human clinical trials, and animal models, providing a comprehensive look at how cannabis impacts addiction vulnerability. Dr. Hurd highlights critical findings on how prenatal and adolescent exposure to THC—the psychoactive compound in cannabis—can alter brain development, increasing vulnerability to psychiatric disorders and opioid addiction later in life. In contrast, CBD (cannabidiol), a non-psychoactive compound, shows promise as a treatment to reduce opioid cravings, anxiety, and stress, with both preclinical and clinical trials showing long-lasting benefits. This presentation emphasizes the importance of understanding which cannabinoids are being consumed, the risks of high-potency THC products, and how CBD might be harnessed for harm reduction in the opioid crisis. Dr. Hurd’s work raises urgent questions for public health, cannabis policy, and medical practice—particularly as legalization expands. Whether you're a researcher, clinician, policymaker, or advocate, this talk offers invaluable insights into the science of cannabis and addiction. Dr. Yasmin Hurd is the Ward-Coleman Chair of Translational Neuroscience and the Director of the Addiction Institute at Mount Sinai. This video is her presentation to the Innovations in the Science of Cannabis Conference, May 19, 2021, McMaster University.