Acute Myeloid Leukemia AML with granulocytic maturation ; Definition, Key features, symptoms, Diagno скачать в хорошем качестве

Acute Myeloid Leukemia AML with granulocytic maturation ; Definition, Key features, symptoms, Diagno

Acute Myeloid Leukemia (AML) with granulocytic maturation, also known as AML M2, is a subtype of AML characterized by the presence of immature myeloid cells (blasts) alongside maturing granulocytes. This condition is classified under the French-American-British (FAB) system as M2. Key features include: Bone marrow findings: At least 20% of the cells in the bone marrow or blood are blasts, with evidence of granulocytic maturation (≥10% of maturing granulocytic cells). Cytogenetics: A common genetic abnormality in AML M2 is the translocation t(8;21), which results in the formation of the RUNX1-RUNX1T1 fusion gene. This genetic marker is associated with a better prognosis compared to other AML subtypes. Clinical presentation: Symptoms may include fatigue, anemia, infections, and easy bruising due to pancytopenia. Treatment typically involves intensive chemotherapy, and in some cases, hematopoietic stem cell transplantation may be considered. The prognosis depends on factors such as age, genetic mutations, and response to initial therapy #Myeloid