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As vehicles become more sealed, automated, and intensively occupied, automotive cabin air quality is emerging as a critical health and exposure challenge. In this seminar presentation from the 5th SGS IBR Filtration Technology Seminar, Dr John McKeon, Principal at the iAIR Institute, explores why filter efficiency alone is no longer enough. Drawing on experience across emergency medicine, exposure science, filtration testing, and standards development, Dr McKeon reframes cabin air quality as a systems-level, multi-pollutant challenge, influenced by: Particulates, gases, and semi-volatile compounds Human-generated biological aerosols Ventilation modes, recirculation, occupancy, and time The presentation highlights why health-relevant, outcome-based approaches are needed — focusing on reducing what occupants actually inhale in real-world conditions, rather than relying on isolated component performance metrics. This thinking aligns with broader trends already shaping indoor air quality in buildings, including standards such as ASHRAE 241, and raises important questions for the future of automotive filtration, testing, and system design. 🎥 Recorded for the SGS IBR Filtration Technology Seminar.