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Andrew Narvaez is a Junior Mechanical Engineering major in the Randall Research Scholars Program (RRSP). Their research project presentation, "Rational Design of Cannabinoid Extraction Co-Solvents," was completed under the advisement of Dr. Pete Ludovice from the College of Engineering Department. Project Description: The therapeutic application of cannabinoid compounds from domestic cannabis is growing exponentially. The State of Alabama passed a law almost three years ago to grow and process cannabis for application to a variety of adverse pathologies. However, therapeutic formulation of cannabinoids is in its infancy because it randomly extracts cannabinoids and cannabinoid mixtures based on the extraction process. Cannabinoids perform optimally in a mixture, and extraction processes do not reflect this. Computer modeling of which solvents preferably dissolve various cannabinoids in supercritical CO2 will rationally guide experimental extraction to produce custom therapeutic mixtures that are significantly more effective than current cannabis products. These optimized mixtures can then be tested against the numerous pathologies targeted in the Alabama Medical Cannabis Law and enhance the growth of this important industry in the State of Alabama.