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Oncoscience published this research paper in Volume 9, entitled, “Association between tumor mutations and meningioma recurrence in Grade I/II disease” by researchers from the Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY; The Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; Sema4, A Mount Sinai Venture, Stamford, CT. #openaccess #braintumorresearch #scientificresearch #cancer #cancerresearch #meningioma #openscience #peerreview #journal #brain #research #researchpaper DOI - https://doi.org/10.18632/oncoscience.570 Corresponding authors - Jonathan T. Dullea - [email protected] Abstract Background: Meningiomas are common intracranial tumors with variable prognoses not entirely captured by commonly used classification schemes. We sought to determine the relationship between meningioma mutations and oncologic outcomes using a targeted next-generation sequencing panel. Materials and Methods: We identified 184 grade I and II meningiomas with both 90 days of post-surgical follow-up and linked targeted next-generation sequencing. For mutated genes in greater than 5% of the sample, we computed progression-free survival Cox-regression models stratified by gene. We then built a multi-gene model by including all gene predictors with a p-value of less than 0.20. Starting with that model, we performed backward selection to identify the most predictive factors. Results: ATM (HR = 4.448; 95% CI: 1.517–13.046), CREBBP (HR = 2.727; 95% CI = 1.163–6.396), and POLE (HR = 0.544; HR = 0.311–0.952) were significantly associated with alterations in disease progression after adjusting for clinical and pathologic factors. In the multi-gene model, only POLE remained a significant predictor of recurrence after adjusting for the same clinical covariates. Backwards selection identified recurrence status, resection extent, and mutations in ATM (HR = 7.333; 95% CI = 2.318–23.195) and POLE (HR = 0.413; 95% CI = 0.229–0.743) as predictive of recurrence. Conclusions: Mutations in ATM and CREBBP were associated with accelerated meningioma recurrence, and mutations in POLE were protective of recurrence. Each mutation has potential implications for treatment. The effect of these mutations on oncologic outcomes and as potential targets for intervention warrants future study. Keywords - meningioma, molecular genomics, POLE, ATM, CREBBP About Oncoscience Oncoscience is a traditional, peer-reviewed, bio-medical oncology research journal with FREE publication for authors and open-access for readers. To learn more about Oncoscience, please visit https://www.oncoscience.us/ and connect with us: Facebook - https://www.facebook.com/Oncoscience Twitter - https://twitter.com/OncoscienceJrnl Instagram - https://www.instagram.com/oncosciencejrnl/ YouTube - / @oncosciencejournal LinkedIn - https://www.linkedin.com/company/oncoscience/ Media Contact [email protected] 18009220957