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Patrick Lewis, PharmD, Senior Director, Medical Affairs at Amryt Pharma discusses the treatment options for patients with acromegaly. Acromegaly is a rare endocrine disorder due to excess levels of growth hormone (GH). In many cases, the excess of GH is caused by a benign tumor on the pituitary gland. Common symptoms include subtle skeletal overgrowth; soft tissue swelling (tongue, heart, kidney, colon, and vocal cords); unusually prominent forehead and heavy brow ridge; protruding lower jaw; overbite; skin thickening; increased shoe and ring size; hypertension; increased perspiration; headaches; paresthesia; and sexual dysfunction. However, due to the insidious nature at which acromegaly symptoms develop, there is an average diagnostic delay of 5.5 years. First treatment option is surgery of the benign tumor. If surgery is not an option or not successful, there are currently four orphan drugs approved to treat acromegaly. They either stimulate somatostatin receptors (octreotide, octreotide-oral, pasireotide) or inhibit GH receptors (pegvisomant). As noted by Dr. Lewis, first line medical therapy are the injectable somatostatin receptor analogs (octreotide, pasireotide) but if the person cannot tolerate the injections but responds to treatment, oral octreotide is another option. Second and third line therapies include pegvisomant or radiation therapy. To learn more about acromegaly, visit our learning center at checkrare.com/acromegaly/