Organ-on-chip innovation: modeling the complex tumor microenvironment for drug discovery скачать в хорошем качестве

Organ-on-chip innovation: modeling the complex tumor microenvironment for drug discovery

A Live30 webinar with Bioinsight. Modelling the highly complex tumor microenvironment (TME) poses a great challenge to those studying cancer in preclinical drug discovery, particularly due to the limitations of animal models. This webinar explores the modelling of the multicellular TME of pancreatic cancer on a fit-for-purpose vascularized spheroid-on-chip model. The head of the cancer team at Dynamic42 will highlight cutting-edge developments in organ-on-chip technology, such as integrating immune responses, perfusion, and vascular systems with tumor spheroids in a biochip. In addition, researchers from the Heinrich-Heine University in Düsseldorf will present data from their proof-of-concept study detailing the success of vorinostat (SAHA), an FDA-approved histone deacetylase inhibitor, in reducing tumor cell viability and endothelial integrity in this spheroid-on-chip model. In this webinar: / Learn how to replicate the intricate tumor microenvironment of pancreatic cancer (PDAC) using spheroids-on-chip / See data showing that dynamic drug administration of SAHA (72h) showed significantly impaired viability of PDAC spheroids, while integrity of the endothelial layer stayed intact / Gain an outlook on the significance of such cancer-on-chip models and those developed in reducing reliance on animal experiments and further translation into the clinic