Patient Specific Brain Organoids for In Vitro Modeling of Neurodegenerative Diseases скачать в хорошем качестве

Patient Specific Brain Organoids for In Vitro Modeling of Neurodegenerative Diseases

Presented By: Gemma Gomez Giro, BSc, MSc, PhD Speaker Biography: Gemma Gomez Giro is a passionate scientist whose work is focused on neurodevelopment and neurodegeneration. She received her B.Sc. in Biomedicine from the Autonomous University of Barcelona, and continued her studies there to receive her M.Sc. at the Pompeu Fabra University. Directly after her master’s, she moved to Germany to intern at the German Centre for Systems Biomedicine, to gain primary hands-on experience in the field of Alzheimer’s disease. Her academic interests in the neuroscience field motivated her to pursue doctoral studies, receiving her PhD by the Westfälische Wilhelms-Universität in Münster, Germany, for her work focused on a rare form of dementia in children, in 2019. After, Gemma became a postdoctoral researcher at the Luxembourg Center for Systems Biomedicine (LCSB) in Luxembourg within the CONNECT-FET-proactive project, working together with an interdisciplinary team of researchers in multiple universities across Europe to develop an on-chip in vitro model of the brain-to-gut axis and use it to study its involvement in Parkinson’s disease, until 2023. She currently holds a Lead project scientist position at OrganoTherapeutics, a biotech company in Luxembourg which uses cutting-edge human-specific organoids for the discovery and development of effective drug candidates targeting Parkinson’s disease. She will use her expertise in on-chip models and will be in charge of generating the brain cyborganoids within the NAP project: twin-on-a-chip brains for monitoring individual sleep habits. Webinar: Patient Specific Brain Organoids for In Vitro Modeling of Neurodegenerative Diseases Webinar Abstract: Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key features of early human brain, they have emerged as novel model systems to investigate human brain development and disorders in vitro. More recently, region-specific brain organoids have come forward as tools to study diseases and processes affecting specific parts of the brain. In this regard, midbrain organoids are essential to study one of the most affected regions in Parkinson’s disease, the midbrain. We make use of Parkinson’s disease patient specific midbrain organoids for the discovery and development of effective drug candidates, which target neurodegeneration. These models are complex and recapitulate many features of the human midbrain, including the presence of dopaminergic, glutamatergic, GABAergic and serotonergic neurons, astrocytes, oligodendrocytes, microglia and other cell types. We focus on disease relevant phenotypes including the loss of dopaminergic neurons, the appearance of alpha-Synuclein aggregates and neuroinflammation. Our phenotypic approach allows for the detection of disease associated conditions as well as their amelioration after drug treatment. Importantly, this is not limited to screening for efficacy of novel small molecule drugs, but can also cover the testing of anti-sense oligonucleotides, peptides or other therapeutic approaches. We are committed to the further development of our models and the improvement of assays and computational tools to perform deep phenotyping of our models to better detect cellular defects and their rescue following compound treatments. Earn PACE Credits: 1. Make sure you’re a registered member of Labroots (https://www.labroots.com/) 2. Watch the webinar on YouTube or on the Labroots Website (https://www.labroots.com/ms/webinar/p...) 3. Click Here to get your PACE credits (Expiration date – March 05, 2027): (https://www.labroots.com/credit/pace-... Labroots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc