Navigating Primary Biliary Cholangitis (PBC): Diagnosis and Modern Treatment Strategies скачать в хорошем качестве

Navigating Primary Biliary Cholangitis (PBC): Diagnosis and Modern Treatment Strategies

MEDIMYST: Unveiling Rare Organ Diseases (   / @medimyst  ) MediMyst explores the often-unheard world of rare organ diseases, empowering patients with clear explanations and fostering a supportive community. We translate complex medical jargon, illuminate hidden symptoms, and offer the latest research. Join us and become a champion for rare disease awareness. #RareDiseases #MedicalMysteries #PatientSupport #Empowerment #HopeForRareDiseases #JoinTheFight #UnderstandingHealth PCB - Unlocking the Path to Managing CHRONIC Liver Disease with Breakthrough Therapies PRIMARY BILIARY CHOLANGITIS (PBC) is a chronic liver disease caused by the gradual DESTRUCTIONof the bile ducts within the liver, leading to bile accumulation, liver inflammation, and eventually liver cirrhosis. PBC predominantly affects middle-aged WOMEN, and its etiology remains enigmatic but is believed to be AUTOIMMUNE in nature. DIAGNOSIS of PBC largely hinges on the presence of antimitochondrial antibodies (AMAs) detected in the blood, found in 90-95% of patients. Levels of liver enzymes, particularly alkaline phosphatase (ALP), are also elevated. Confirmatory diagnosis may require liver biopsy, where histological examination reveals bile duct DESTRUCTION and INFLAMMATION. **Early detection through blood tests and symptom awareness is critical for effective management of PBC. TREATMENT centers on slowing disease progression and alleviating symptoms. Ursodeoxycholic acid (UDCA) is the first-line THERAPY that can improve liver function and may delay the need for a liver transplant. For patients unresponsive to UDCA, obeticholic acid is an alternative approved by the FDA that can reduce ALP levels. *Liver transplantation is a viable option for advanced PBC with liver failure. Effective MANAGEMENT includes regular monitoring of liver function, managing associated symptoms such as fatigue and pruritus, and addressing the impact on patients' quality of life. Primary Biliary Cholangitis, Chronic Liver Disease, Antimitochondrial Antibodies, Ursodeoxycholic Acid, Alkaline Phosphatase, Liver Transplant, Obeticholic Acid, Autoimmune Hepatitis, Liver Biopsy. References: 1. "Primary biliary cholangitis: Adult and pediatric treatment guidelines" - Hepatology 2. "Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection" - Therapeutic Advances in Gastroenterology 3. "Liver transplantation for primary biliary cholangitis: A comparative analysis of outcomes" - Liver Transplantation