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LIGHT (Lymphatic Imaging, Genomics, and Phenotyping Technologies) What if we could make the invisible lymphatic system visible? Though invisible to the naked eye, the lymphatic system plays a major role in the healthy function of all major organs. Patients with primary lymphatic disease (LD) are often misdiagnosed, leading to inappropriate treatments, prolonged hospital stays, possible disfigurement and disability, and even death. Beyond LD, this difficulty in assessing lymphatic health impairs our understanding of its role in a variety of common, chronic diseases. Cancer, obesity, heart failure, inflammatory bowel disease, chronic kidney and liver diseases, autoimmune disorders, and neurodegenerative diseases all have a lymphatic component. The Lymphatic Imaging, Genomics, and pHenotyping Technologies (LIGHT) program seeks comprehensive diagnostic solutions across three technical areas: diagnosis and monitoring through biomarker discovery; imaging technologies; and prevention, prediction, and diagnostic confirmation through genetics, epigenetics, and models of lymphatic dysfunction. If successful, LIGHT will not only illuminate the unseen aspects of the lymphatic system through novel diagnostic approaches, but also significantly improve patient care and outcomes by gaining a deeper understanding of its critical role in health. Program Manager: Dr. Kimberley Steele Learn more at: https://arpa-h.gov/research-and-fundi...