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This video provides an overview of the Oncotype DX Breast Recurrence Score® test, which helps guide post-surgical treatment decisions for patients with stage I-III, HR+, HER2 invasive breast cancer. The Oncotype DX Breast Recurrence Score test aims to answer three key questions to help guide your treatment plan: • What is my risk of recurrence? • How will my tumor likely respond to treatment? • Might I benefit from chemotherapy? Using a tissue sample removed during biopsy or surgery, the test analyzes your tumor for 16 cancer-related genes. The test then generates a result on a scale of 0-100. The lower the score, the lower the likelihood of your cancer coming back somewhere else in your body if you take endocrine therapy alone. The higher the score, the higher the likelihood of your cancer returning. As your score increases, the magnitude of chemotherapy benefit also increases. This test gives valuable insights into how your cancer may respond to hormone therapy alone and whether the addition of chemotherapy may be beneficial.(1-4) 1. Paik S, et al. J Clin Oncol. 2006;24(23):3726-3734 2. Albain KS, et al. Lancet Oncology. 2010;11(1):55-65 3. Sparano JA, et al. N Engl J Med. 2018;379(2):111-121 4. Kalinsky K, et al. N Engl J Med. 2021;385(25):2336-2347 Information presented is not intended as medical advice and should not replace professional medical treatment. Talk to your healthcare provider about whether genomic testing is right for you.