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Kathrin Heinrich, MD, Ludwig-Maximilians-Universität München, Munich, Germany, highlights the need to address sex and gender differences in colorectal cancer research. She emphasizes performing retrospective analyses and implementing sex as a pre-specified subgroup analysis in future clinical trials. Prospective clinical data, including pharmaceutical drug monitoring, are essential to determine whether male and female patients should be treated differently. It is also important to incorporate gender analysis into clinical trials using tools like quality of life questionnaires to better understand the impact on patients. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.