David Olson: Psychedelics, Psychoplastogens, Brain Chemistry, Microdosing, & Mental Health | #46 скачать в хорошем качестве

David Olson: Psychedelics, Psychoplastogens, Brain Chemistry, Microdosing, & Mental Health | #46

Nick talks to medicinal chemist Dr. David Olson, whose lab at the University of California-Davis studies a class of compounds called ‘psychoplastogens,’ which are small molecules capable of promoting neural plasticity. His lab is on the cutting edge when it comes to understanding the mechanisms by which psychedelics and other psychoactive drugs work in the brain, and they spent most of our conversation discussing this research. They touch on everything from some of the latest research from his lab, to new tools they are developing and using to understand these drugs, to the question of whether it’s likely that we will be able to produce non-hallucinogenic drug variants of classic psychedelics, capable of eliciting therapeutic mental health outcomes but without triggering psychedelic states of consciousness. David also described some research suggesting that there might be downsides to microdosing psychedelics on a regular basis. USEFUL LINKS: Sign up for the weekly Mind & Matter newsletter [https://mindandmatter.substack.com/] Follow & Support Nick's work: https://linktr.ee/trikomes Download the podcast & follow Nick at his website [https://www.nickjikomes.com] Support the show on Patreon & get early access to episodes [  / nickjikomes  ] Athletic Greens, comprehensive daily nutrition (Free 1-year supply of Vitamin D w/ purchase) [https://athleticgreens.com/partner/d3...] Organize your digital highlights & notes w/ Readwise (2 months free w/ subscription) [https://readwise.io/nickjikomes/] Start your own podcast (get $20 Amazon gift card after signup) [https://www.buzzsprout.com/?referrer_...] Buy Mind & Matter T-Shirts [https://www.etsy.com/shop/OURMIND?ref...] ​​​ Learn more about our podcast sponsor, Dosist [https://dosist.com/] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison. 0:00:00 Episode Intro 0:04:09 David Olson Intro 0:11:01 Engineering New Drugs 0:14:12 Ibogaine 0:21:56 Plasticity & Psychoplastogens 0:26:25 Non-Hallucinogenic Psychedelic Variants 0:33:39 Are Hallucinogenic Drug Effects Beneficial? 0:40:38 Neuropsychiatric Disease 0:46:59 Psychedelics & Neuroplasticity 0:51:17 Short-Acting Psychedelics 0:55:14 Microdosing & Neuroplasticity 1:02:26 Non-Brain Effects of Psychedelics 1:05:30 Why David Went Into Psychedelic Science