Phage Therapy: Using Viruses to Kill Antibiotic-Resistant Bacteria скачать в хорошем качестве

Phage Therapy: Using Viruses to Kill Antibiotic-Resistant Bacteria

Antimicrobial Resistance threatens to cause ten million deaths annually by 2050, driven by pathogens like the multidrug-resistant ESKAPE group. This video details how bacteriophages, viruses that exclusively infect bacteria, offer a precise biological solution. We explore the lytic cycle mechanism, the critical safety screening required to eliminate temperate phages, and the design of phage cocktails to prevent bacterial resistance. Learn how synthetic biology is engineering phages with CRISPR-Cas systems to degrade specific antibiotic resistance genes, effectively resensitizing bacteria to existing drugs. 00:00: Antibiotic Resistance: The Global Threat 01:07: Bacteriophages: Structure and Specificity 02:06: Lytic Phages: Killing the Host 03:03: Temperate Phages and Safety Concerns 04:03: Phage Cocktails: Overcoming Resistance 05:01: Clinical Application and Pharmacokinetics 05:53: Specificity and Biofilm Penetration 06:49: Regulatory Hurdles and Immune Response 07:39: Synthetic Biology: Engineering Phage Precision