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In this video, I dive into the latest science behind why lipedema causes such chronic and intense pain. Many people know lipedema as a condition marked by disproportionate fat and resistance to diet and exercise, but the question I hear most is: why does it hurt so much? I explain how lipedema pain is rooted in complex biological changes in the affected tissue. First, hypoxia and microcirculation failure happen because fragile, leaky blood vessels can’t supply enough oxygen to rapidly growing fat cells. This lack of oxygen triggers distress signals your body interprets as pain. Next, chronic inflammation takes hold as the immune system battles inflamed fatty tissue, releasing chemicals that cause aching and tenderness. Then, nerve fibers become hypersensitive and even sprout new branches, leading to heightened pain responses and tenderness known as allodynia. Finally, a buildup of fibrotic tissue traps nerves and blood vessels, worsening pain and creating a vicious cycle. While conservative treatments like compression and manual lymphatic drainage provide relief, they cannot reverse these cellular changes permanently. The only way to break this pain cycle is to physically remove the diseased tissue through specialized lymphatic-sparing liposuction—a therapeutic surgery designed to reduce inflammation and nerve compression. Hello, I’m Dr. Markelov, expert lipedema surgeon, Lipedema specialist, and double board certified plastic surgeon specializing in lipedema. 🔗 SOCIALS + WEBSITE Website - https://www.markelovmd.com/ Instagram - / markelovmd Facebook - / markelovmd 0:00 Introduction 0:31 Pain Is Not Just a Symptom 0:39 Factor №1 Hypoxia & Microcirculation Failure 1:28 Factor №2 Chronic Inflammation 1:55 Factor №3 Nerve Changes & Hypersensitivity 2:33 Factor №4 Fibrosis & Nodules 3:10 Conservative Treatments 3:24 Surgical Solution