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Alexander Disease Research Update, Podcast episode #30 https://www.buzzsprout.com/1819681/ Episode #30 was recorded on January 23, 2026, and uploaded today. Debra Levin and Amy Waldman join to talk about the following recent publications: Levin D, Levin J, Joung J, Liu GW, Donaher J, Faig W, Waldman AT. 2025. Language Skills in Patients with Alexander Disease. American Journal of Speech-Language Pathology 35:211-225. PMID:41253129 https://doi.org/10.1044/2025_ajslp-25-00185 Key message: Speech-language impairments are common in individuals with Alexander disease, especially those with the cerebral form, and many interventions are available to help improve communication. Waldman AT, Takanohashi A, Joung JY, Liu GW, Arnold K, Pizzino A, Faig W, Woidill S, Narula S, Vanderver AL. 2026. Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease. Annals of Clinical and Translational Neurology (in press) PMID:41513585 https://doi.org/10.1002/acn3.70305 [full text] Key message: GFAP levels are elevated in CSF and blood of individuals with Alexander disease, but not necessarily stable, especially in those under the age of 8. You can send questions about any aspect of Alexander disease to this email, and we will try to address them in subsequent podcasts: amessing@wisc.edu Feedback is also always welcome.