Henoch-Schonlein Purpura (HSP) Case Study | Physiology скачать в хорошем качестве

Henoch-Schonlein Purpura (HSP) Case Study | Physiology

So, here we are with a case study related to rheumatology. As we know applied medicine is hard to comprehend at times and case studies are really helpful to get a better understanding of the topic. So, stay tuned. ▬ 📌 Henoch-Schonlein Purpura (HSP) We will be discussing Henoch-Schonlein Purpura, which is an autoimmune disorder more common in children affecting the joints and resulting in skin manifestations. So, let’s dive in! 🟡 It is more common in children and males are predominantly affected. 🟡 There is also an association with HLA B 34 HLA DR B 1 allele 1. HSP is a feature of the genetically determined auto-inflammatory disease, familial Mediterranean fever (FMF) due to the same genetic associations. ▬ 📌 Henoch-Schonlein Purpura (HSP) Pathogens Pathogens involved in Henoch-Scholein Purpura are: 🔵 Group A beta-hemolytic streptococcus (GAS) has been widely studied and found in 20–50% of patients with acute HSP by serological tests or bacterial cultures 🔵 Bartonella henselae (12 of 18 HSP patient sera were positive) 🔵 Other HSP-associated pathogens have been reported 🔵 Staphylococcus aureus, 🔵 Helicobacter Pylori, 🔵 Hemophilus parainfluenza, 🔵 Coxsackie virus, 🔵 Adenovirus, 🔵 Hepatitis A virus, 🔵 Hepatitis B virus You can learn more about Henoch-Scholein Purpura pathophysiology in the video. ▬ 📌 Henoch-Schonlein Purpura (HSP) Clinical Presentations The mnemonic HSP will help you remember them easily. So, here the: 🟢 H stands for hematuria 🟢 S stands for a small child 🟢 P stands for palpable purpura on the buttocks The last A in purpura Stands for the significance of Ig A-mediated immune response. ▬ 📌 Henoch-Schonlein Purpura (HSP) Lab investigations ⚫️ Platelet count and coagulation studies to look for other causes of bleeding. ⚫️ Laboratory tests to rule out other causes of vasculitis. ⚫️ Evaluation of kidney function by blood pressure check, creatinine level, electrolytes, and urine sample. ⚫️ In some patients, a biopsy may be taken of the skin, kidney, or other tissue. Biopsies in patients with HSP often show high levels of a specific type of immune protein, called immunoglobulin A (IgA). ⚫️ Imaging of the bowels may be performed if abdominal pain is severe. ▬ 📌 Henoch-Schonlein Purpura (HSP) Treatment Though, there is no specific treatment for Henoch-Scholein Purpura, but: 🟢 Joint pain can often be controlled with rest and over-the-counter medications such as acetaminophen, ibuprofen, or naproxen. 🟢 Steroids given by mouth or through an IV infusion are typically given for severe abdominal pain. 🟢 Kidney disease has to be closely monitored. We will be discussing Henoch-Schonlein's purpura in detail including the pathogenesis, signs and symptoms, investigations, and treatment in the video. So, do watch the complete video to learn about HSP for USMLE preparation. Wait wait wait… Are you going to leave the page? I have a suggestion for you! Please have a look at our related medical videos here! ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻‍⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More