David Reiter: Anomalous T2 Relaxation in Cartilage скачать в хорошем качестве

David Reiter: Anomalous T2 Relaxation in Cartilage

An audioslide accompanying the MRM Editor's pick for September 2016, entitled "Anomalous T2 relaxation in normal and degraded cartilage" by David A. Reiter from National Institutes of Health, USA. ============================ HIGHLIGHTS: This work’s objective was to examine anomalous T2 models of relaxation and cartilage pragmatically with the goal of improving the early detection of osteoarthritis. Monte Carlo numerical simulations were used to both examine the ability to discriminate between the decays of each model under idealized acquisition conditions as well as establish accuracy and precision estimates of model fit parameters under clinical condition. In-vitro experiments of cartilage explants were used to examine the range of anomalous relaxation parameters for normal and mildly degraded cartilage and for comparison of these parameters with biochemically drive matrix composition. Three anomalous relaxation models—the stretched Mittag-Leffler, stretched exponential, and biexponential functions- provides alternative and physically plausible models for T2 relaxation. The stretched exponential model more accurately describes transverse relaxation data over the entire acquisition time and has modest acquisition requirements. Alpha from stretched exponential model correlates well with proteoglycan content, highlighting its potential as a biomarker for human studies