Oncogenetic landscape of lymphomagenesis in coeliac disease скачать в хорошем качестве

Oncogenetic landscape of lymphomagenesis in coeliac disease

To cite: Cording S, Lhermitte L, Malamut G CELAC network, et al. Oncogenetic landscape of lymphomagenesis in coeliac disease. gut 2022;71:497-508. Read the full article here: http://dx.doi.org/10.1136/gutjnl-2020... Objective: Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of coeliac disease (CeD), often preceded by low-grade clonal intraepithelial lymphoproliferation, referred to as type II refractory CeD (RCDII). Knowledge on underlying oncogenic mechanisms remains scarce. Here, we analysed and compared the mutational landscape of RCDII and EATL in order to identify genetic drivers of CeD-associated lymphomagenesis. Conclusions: Mutations activating the JAK1-STAT3 pathway appear to be the main drivers of CeD-associated lymphomagenesis. In concert with mutations in negative regulators of NF-κB, they may favour the clonal emergence of malignant lymphocytes in the cytokine-rich coeliac intestine. The identified mutations are attractive therapeutic targets to treat RCDII and block progression towards EATL.