mTOR Science- Muscle Growth vs. Longevity скачать в хорошем качестве

mTOR Science- Muscle Growth vs. Longevity

Click Here to Subscribe: http://Bit.ly/ThomasVid My Favorite Matcha is Ujido: https://ujido.com/pages/thomas-delauer Check out Celsius HERE: http://Celsius.com This video does contain a paid partnership with brands that help to support this channel. It is because of brands like these that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion. Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-op... Follow More of My Daily Life on Instagram:   / thomasdelauer   It's important that I am honest and to say that this video does have a sponsorship from Celsius & Ujido, supporting them is a good way to support my channel! Special Thanks to my team and Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student - for working diligently on research as well! Mammalian target of rapamycin (mTOR) was named because a drug called rapamycin inhibited a protein that was then named, target of rapamycin (TOR). The “m” is because it’s in mammals (zebra fish TOR is, similarly, zTOR). mTOR is central to the opposing biological processes of growth and longevity. mTOR is thought to promote growth and decrease longevity. Basically, any process you can think of relating to muscular growth and longevity probably has some relationship to mTOR. Here are some examples: Exercise activates mTOR signaling in skeletal muscles (growth) mTOR inhibits autophagy (longevity) Insulin activates mTOR (growth) Sirtuin proteins inhibit mTOR (longevity) BCAAs activate mTOR (growth) Fasting inhibits mTOR (anti-growth and longevity) And, as precited by its pathetic name, rapamycin increases (longevity), at least in mice How exactly does mTOR impact all these processes? Well, it’s kind complicated [show image below] and there are actually two different mTOR complexes (mTOR1 and mTOR2) that have slightly different functions. So, for the sake of simplicity let’s just say this: mTOR is a kinase. This means that mTOR acts to regulate the activities of other proteins by adding a phosphate group from ATP to them. Depending on what protein it adds the phosphate to, and where on that protein it does so, is can either activate of inhibit its target and pathways downstream. The message, in its simplest form, is that mTOR activity makes you live hot (and strong) but die young. But since when is science ever simple? What annoys me is that people tend to be scared of anything that activates mTOR because they are afraid it’s going to kill them. This is problematic thinking for two reasons: (1) Biology is all about balanced cycles. You need periods of growth (anabolism) and breakdown (catabolism). If you’re all anabolism (like a body builder) you will die young. However, if you’re all catabolism, you’ll die even younger. In fact, one of the leading risk factors for death in the elderly is low muscle mass. You need a functional level of muscular power to live and thrive. No mTOR and you’d wither away. In short, you do want to activate mTOR on occasion. Just don’t overdo it. “Extremes are easy, the challenge is balance.” “ (2) The inside of your body is NOT a homogenous blob! Why do people always forget that fact? Just because you activate mTOR in once place doesn’t mean you activate it everywhere. For example, when you work out you activate mTOR in your skeletal muscle but might actually decrease mTOR activity in your brain. Thus, it’s possible, and I would argue probable (such studies can’t be done in humans without cutting into their brains), that exercise activates muscular mTOR but inhibits brain mTOR, giving you the exact organ-specific balance of activity that you want! Fasting Guides How to do Intermittent Fasting: Complete Guide:    • How to do Intermittent Fasting: Compl...   Complete Women's Guide to Intermittent Fasting:    • Complete Women's Guide to Intermitten...   Beginners Guide to Prolonged Fasting | 24-72 Hour Fasting Instructions:    • Beginners Guide to Prolonged Fasting ...   Fasting Guidelines: What You CAN and CANNOT Drink:    • Fasting Guidelines: What You CAN and ...   Intermittent Fasting over Age 40 : The Complete Guide:    • Intermittent Fasting over Age 40 : Th...   Keto Guides How to do a Keto Diet: The Complete Guide:    • Video   Keto Over Age 50 - Instructional Guide:    • Keto Over Age 50 - Instructional Guide   Full Beginner Keto Meal Plan: Exactly What to Eat:    • Full Beginner Keto Meal Plan: Exactly...   Nicholas Norwitz - Oxford PhD Researcher and Harvard Med Student: https://www.dpag.ox.ac.uk/team/nichol...