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A 45 years old man complaining of sense of chest oppression, CT revealed a large paraesophageal posterior mediastinal "mass lesion", 5 x 7cm. He was referred for EUS that showed a large cyst with turbid fluid inside, adjacent but separated from muscularis propria, pericardium, left atrium and right pulmonary artery, looks like a Duplication or Bronchial cyst. No FNA was done to avoid secondary infection. The standard of care is surgery to avoid leakage and mediastinitis of this dangerous area. I think only 3 case reports in the literature described cysto-esophagostomy using LAMS, in poor surgical risk patients, active Link is below. However I have a series of 3 cases of needle knife deroofing and fenestration of BULGING duodenal duplication cysts, to avoid possible major surgery due to their close relationship to the papilla. https://journals.lww.com/acgcr/fullte... We present a case of a large mediastinal pancreatic pseudocyst that was drained endoscopically through a transesophageal approach by performing a cyst esophagostomy and placement of a lumen-apposing stent. We performed an extensive review of literature and found only 2 other case reports of mediastinal pseudocysts that were drained through the transesophageal route.3,4.