Doering-LaFlamme Allene Synthesis скачать в хорошем качестве

Doering-LaFlamme Allene Synthesis

The Doering-LaFlamme allene synthesis is a reaction in organic chemistry that converts alkenes to the corresponding allenes by the insertion of a carbon atom. Reaction mechanism: 1. The haloform is deprotonated by a strong base. 2. Generation of the dihalocarbene that reacts in situ with the olefin to generate a dihalocyclopropane. 3. The alkyllithium reacts with the dihalocyclopropane (metal-halogen exchange) followed by the loss of lithium halide to generate a cyclopropylidene, or carbenoid. 4. The cyclopropylidene rearranges to the corresponding allene. References: https://nrochemistry.com/doering-lafl... Seminal publication: J.Am.Chem.Soc. 1956, 78, 5447-5448. https://doi.org/10.1021/ja01601a079