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It's a significant global public health threat putting modern medicine at risk. Antimicrobial resistance is when the germs that cause infections no longer respond to the medicines used to treat them. Largely caused by the overuse and misuse of antibiotics and antivirals in humans and farming, antimicrobial resistance is responsible for millions of deaths. A study published in the medical journal the Lancet this month found 1.06 million people died from drug-resistance infections in 1990, a figure that rose to 1.2 million in 2019 before dropping slightly to 1.14 million in 2021. The paper predicts antibiotic-resistant infections will kill more than 39 million people between 2025 and 2050. Ellen Coulter reports. Subscribe: https://ab.co/3yqPOZ5 Welcome to ABC News In-depth, where you'll find our long-form journalism and other videos to help you understand what's going on in the world around you. Watch more ABC News content ad-free on ABC iview: https://ab.co/2OB7Mk1 For more from ABC News, click here: https://ab.co/2kxYCZY Get breaking news and livestreams from our ABC News channel: / newsonabc Like ABC News on Facebook: / abcnews.au Follow ABC News on Instagram: / abcnews_au Follow ABC News on Twitter: / abcnews Note: In most cases, our captions are auto-generated. #ABCNewsIndepth #ABCNewsAustralia