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This ***-min micro-lecture explores serotonin's multi-faceted roles in both the central and peripheral nervous systems, as reviewed in Pourhamzeh et al's 2022 review "The Roles of Serotonin in Neuropsychiatric Disorders." Pourhamzeh's review (and this micro-review) outline how serotonin (5‑HT) influences essential biological functions such as mood regulation, memory formation, appetite, and sleep, while also shaping complex patterns of human behavior. I. How Serotonin Is Made and How It Works The authors describe the biochemical pathway through which serotonin is synthesized and explain how it interacts with seven major receptor families. Each receptor subtype triggers distinct intracellular responses, helping to explain why serotonin can produce widely different—and sometimes opposing—physiological effects depending on where and how it is released. II. Serotonin and Mental Health A major focus of the review is the connection between serotonergic dysfunction and neuropsychiatric disorders. Irregularities in 5‑HT signaling are linked to conditions such as: Depression Autism spectrum disorder Schizophrenia Anxiety and related mood disturbances By integrating findings from experimental and clinical research, the authors highlight how disruptions in serotonin pathways contribute to the molecular basis of these illnesses. III. SSRIs and Other Treatments The paper also evaluates the effectiveness and limitations of Selective Serotonin Reuptake Inhibitors (SSRIs) and other pharmacological treatments. It discusses how these medications alter serotonin availability, their therapeutic benefits, and the side effects that can arise from long‑term use. IV. Why This Matters By mapping serotonin’s many functions and receptor‑specific actions, the review provides a clearer understanding of how 5‑HT signaling shapes both healthy and disordered brain states. This knowledge helps identify new therapeutic targets and supports the development of more precise treatments for complex psychiatric conditions. #neuroscience #serotonin #mentalhealthresearch #mentalhealth #neuropsychiatry #ssris #brainscience #serotoninboost #synapticplasticity #depressionresearch #tryptophan #SERT #neurobiology #5ht2a #5HT #depression #mood #anxiety #dorsalraphe #fluoxetine #sertraline #prozac @BrennaBrayPhD @NIMHgov @NIHVideoCast @NIH_NCCIH @Motivate_Neuroplasticity @nunmedu @naropauniversity @BBRFoundation @naropaallianceforpsychedel7015 @neurochallenged @Neuroscience @DrCarolineLeaf @BosqueNeuroscience @prsneurosciences @neuroscienceonline2420 @uofubraininstitute @PacificNeuroscienceInstitute @TheAPAVideo @AmericanPsychiatricAssociation @psychiatrylectures9556 @serotonin_records @serotonin7066 @Serotonin99 @SerotoninSyndromeDJ @antidepressantprod @PsychiatryClinic @psychiatrylectures9556 @brainscience99 @Science_and_Brain @scienceinnovativebrain @themightybrain2024 @thisisyourbrainonscience4597 @scienceandfun @PsychiatryLectures @psychiatrypsychotherapy6939 @ThePsychedelicScientist @psychedelicsupport @Psychedelic @PsychedelicSpotlight @psykedeliskvetenskap @PsychedelicUniverse @PsychedelicUniverse @psychedelicminiatures @PsychedelicsCom @ThePsychedelicMuse @PsychedelicsToday @PsychedelicsReview @thepsychedelics7680 @mapsmdma @yalepsychedelicsciencegrou9534 @YalePsychiatry @stanfordpsychedelicscience12 @stanfordpsychiatryandbehav9531 @OxfordPsychedelicSociety @departmentofpsychiatryuniv763 @psychedelicscienceorguk28 @psychedelic_center_mexico @psychedelicresearchgroup5348 @mghcenterfortheneuroscienc28 @UCBCSP @thecenterforadvancedpsyche511 Source: Pourhamzeh, M., Moravej, F. G., Arabi, M., Shahriari, E., Mehrabi, S., Ward, R., Ahadi, R., & Joghataei, M. T. (2022). The Roles of Serotonin in Neuropsychiatric Disorders. Cellular and molecular neurobiology, 42(6), 1671–1692. https://doi.org/10.1007/s10571-021-01... (PDF: https://pmc.ncbi.nlm.nih.gov/articles...)