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In this Q&A, Dr. Joseph Mikhael (Chief Medical Officer, International Myeloma Foundation) answers real questions from people living with myeloma, their families and care partners. He tackles questions including rare delayed neurologic side effects after CAR T-cell therapy, what “remission” really means vs “cure,” why myeloma treatments stop working, alternatives when dexamethasone causes severe side effects, and how to think about bone safety, kidney function, and relapse. Topics Covered in this Video: 0:00 - Intro + where to ask questions + IMF education/events and InfoLine 1:19 - CAR T Side Effects: rare delayed neurotoxicity (including paralysis) 2:35 - Couples both diagnosed with myeloma: MGUS prevalence, what we know/don’t know about causes 3:55 - Alternatives to dexamethasone when side effects are severe 5:18 - Heavy lifting and fracture risk (bone disease variability; talk to your team) 6:32 - Why doctors don’t “retry” Revlimid if it worked before (drug resistance) 7:52 - Remission vs cure: what remission means; how “functional cure” is increasing over time 9:36 - “More young women?” testing/awareness vs true incidence; aging population context 10:57 - Smoldering myeloma + worsening kidney function: how to evaluate if myeloma is the cause Don't miss this in-depth Q&A with Dr. Mikhael and be sure to submit your own questions using #AskTheIMF on Facebook, Instagram, or X. Learn more at myeloma.org. Like, Comment, and Subscribe for weekly updates on myeloma research, treatment, and patient support. Have a question that needs more personalized support? Call us! We’re here for you. The IMF’s InfoLine is available to answer your myeloma-related questions and concerns. Call us at 1-818-487-7455, email us at infoline@myeloma.org, or schedule your call at a time that works best for you at: https://www.myeloma.org/infoline. _______________ Improving Lives | Finding the Cure Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy. Subscribe to our channel: / imfmyeloma Visit our website at: https://www.myeloma.org Find us online: Facebook: @myeloma | / myeloma X/Twitter: @IMFMyeloma | / imfmyeloma Instagram: @imfmyeloma | / imfmyeloma LinkedIn: / international-myeloma-foundation Support the IMF | Donate Now! https://fundraise.myeloma.org/give/52... Category Nonprofits & Activism License Standard YouTube License The International Myeloma Foundation is committed to accessibility for all. That’s why all English-language videos uploaded to our YouTube channel feature human-transcribed closed captioning. This ensures more accurate captions for viewers who are Deaf or hard of hearing and improves the quality of automatic translations into other languages for our global audience.