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In Episode 2 of Everything Hormones, Dr. Theresa Ramsey sits down with her longtime mentor and hormone educator, Dr. Neal Rouzier, for an in-depth discussion on the science, controversy, and clinical realities of bioidentical hormone replacement therapy. Dr. Rouzier has spent decades studying and teaching the medical literature on hormone optimization. In this wide-ranging conversation, he and Dr. Ramsey address some of the most debated topics in modern medicine, including: The FDA’s removal of black box warnings on estrogen and testosterone The difference between synthetic hormones and bioidentical estradiol and progesterone Misconceptions surrounding estrogen and breast cancer Progesterone versus progestins Testosterone and prostate cancer Hormones and cardiovascular disease prevention The role of estradiol and testosterone in protecting brain health and reducing Alzheimer’s risk Why “normal” lab ranges may not mean optimal health They also discuss medical education gaps, the influence of outdated training, and the importance of understanding the difference between hormone replacement and hormone optimization. This episode is a candid, research-driven conversation between two clinicians who have spent decades working directly with patients and the medical literature. For patients, practitioners, and anyone seeking clarity in the hormone space, this discussion provides context, evidence, and perspective on topics that are often misunderstood.