T cell expansion in a Xuri™ bioreactor: Pioneers of cell therapy #2 скачать в хорошем качестве

T cell expansion in a Xuri™ bioreactor: Pioneers of cell therapy #2

Successful T cell expansion was a defining innovation that made early CAR T therapies possible. In this episode, explore how the Xuri™ bioreactor played a pivotal role in addressing the challenges of T cell expansion, enabling pioneering researchers to generate enough cells for therapeutic doses. This breakthrough transformed cancer immunotherapy and brought hope to countless patients. Tamara Fedczyna, part of the Cytiva team that supported this revolutionary development, shares the story of a “life-shattering” discovery in the Xuri bioreactor that changed the trajectory of CAR T cell therapy. By overcoming early cell processing challenges, this innovation allowed researchers like Bruce Levine and Carl H. June to grow potent T cells capable of treating patients such as Emily Whitehead, who is now 10 years cancer-free. Key highlights of this episode include: • The early challenges of CAR T manufacturing and how they were overcome. • How the Xuri bioreactor revolutionized T cell culture and expansion. • Lessons from the dedicated teams behind the history of CAR T cell therapy. The Xuri bioreactor continues to enable cutting-edge research, offering a reliable solution for scaling CAR T cell expansion and ensuring consistent results. This critical advancement has paved the way for cancer immunotherapy to evolve and save lives worldwide. Discover more stories from the pioneers of cell therapy: https://www.cytivalifesciences.com/en... Learn about the science behind rocking bioreactor technology: https://www.cytivalifesciences.com/en... Join us as we delve into the origins of T cells in immunotherapy and celebrate the innovation and resilience that continue to advance cell therapy. Episode features: Carl H. June, Sadik Kassim, George White, Tamara Fedczyna, Sonia Bulsara, Aaron Dulgar-Tulloch and Rohin Iyer. Chapters: 00:00 Intro 00:26 Taking a leap of faith on cell therapy 01:01 Challenges of early CAR T manufacturing 02:11 A key discovery in T cell expansion 03:52 How to grow potent T cells to fight cancer 04:33 Pioneering a T cell culture revolution 05:41 Xuri™ cell expansion system 06:20 Lessons from a life in cell therapy 07:52 End #celltherapy #biopharma #cytiva #lifesciences