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Glutamate Excitotoxicity

Visit IvyTutoring.net for a live tutor. In this video, we explore glutamate excitotoxicity, a critical concept for USMLE Step 1. Glutamate, the primary excitatory neurotransmitter in the brain, plays a vital role in synaptic transmission and plasticity. However, excessive glutamate release can lead to neuronal injury and death through overactivation of NMDA receptors, resulting in increased calcium influx and subsequent cellular damage. This process is implicated in various neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases like Alzheimer's and Parkinson's. Understanding the mechanisms of excitotoxicity is essential for recognizing potential therapeutic targets aimed at neuroprotection. Visit https://blakeyoung-shop.fourthwall.com/ to purchase our software. #USMLEStep1 #glutamateexcitotoxicity #neurobiology #medicaleducation #neuroscience #pathophysiology #neurotransmitters #braininjury #medicalschool #exampreparation