008-Alan Green MD: Rapamycin for Longevity in Clinical Practice скачать в хорошем качестве

008-Alan Green MD: Rapamycin for Longevity in Clinical Practice

The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity. Take away points:  -Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice. -In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice.  -It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis. -The drug requires a prescription and should only be used under supervision of a physician -Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin] 02:45 Blagosklonny papers (Blagosklonny 2019) 05:23 Jane Mannick rapalogue paper (Mannick 2014) 08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy 09:14 Elevated mTOR as common factor- Inflammation, fibrosis, 12:03 Rapamycin role to decrease mTOR overview common pathway 14:23 mTOR is essentially command and control of the cell for the last 2 billion years 15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects 16:05 Increased mTOR causes increased innate immune system/inflammation 17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging 19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy 23:00 Alzheimer disease as a disease of senescent cells 26:00 importance of dose timing for Rapamycin 27:00 Anti aging effects on mTOR1 and other effects on mTOR2 32:00 Rapamycin as off patent drug 37:00 Dosing considerations and subjective effects 40:00 Tracking HOMA-IR  (Homeostatic Model Assessment for Insulin Resistance) score 42:00 Improvement in exercise related to maximum cardiac output 45:00 Age associated cardiomyopathy 49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections. 57:00 Personal lifestyle choices If you take rapamycin for longevity, please consider joining the: Rapamycin Clinical Registry https://www.rapamycin.io/ Blagosklonny, Mikhail V. “Rapamycin for Longevity: Opinion Article.” Aging 11, no. 19 (October 4, 2019): 8048–67. https://doi.org/10.18632/aging.102355. Mannick, J. B., G. Del Giudice, M. Lattanzi, N. M. Valiante, J. Praestgaard, B. Huang, M. A. Lonetto, et al. “MTOR Inhibition Improves Immune Function in the Elderly.” Science Translational Medicine 6, no. 268 (December 24, 2014): 268ra179-268ra179. https://doi.org/10.1126/scitranslmed..... https://rapamycintherapy.com/ https://www.robertlufkinmd.com/rapamy... *** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***   / @robertlufkinmd   ** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ** Web: https://robertlufkinmd.com/ Twitter:  / robertlufkinmd   *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content. Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel.  ------------------------------------------------------------------------ #longevity #wellness #antiaging #biologicalage #lifestylemedicine #younger #epigenetics #biohacking #Rapamycin #RobertLufkinMD #alangreen #rapalogue