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NOTE FROM TED: TED does not endorse the use of psychedelics or other regulated substances that can lead to serious health and safety concerns, especially when used outside of accredited research or therapeutic settings. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/t... Neuroscience shows how the brain works, with drug use and drug addiction showing new insights on how neurons work. Kavilas shares his story and dream for where this research can take us. The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse, as well as the learning and memory deficits associated with impoverished rearing environments. Research is at the level of protein biochemistry, neural circuitry and behavioral modeling. The current focus for both addiction and isolation rearing is in adaptations in excitatory neurotransmission. In collaboration with electrophysiologists in the department (Drs Lavin, Seamans, Woodward) we are elucidating the fundamental role of extracellular glutamate homeostatis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx