OSKM: The Four Letters that Lead to Immortality скачать в хорошем качестве

OSKM: The Four Letters that Lead to Immortality

Can old cells produce young cells? Yes—and that simple idea changes everything. In this video I break down why aging is mostly accumulated cellular damage (not a “biological clock”), how iPSCs and the Yamanaka factors (OSKM) work, and why AI + nanotechnology will be crucial to deliver safe, targeted partial reprogramming (OSK) that rejuvenates tissues without erasing identity. I also share takeaways from a longevity event in Madrid, where researchers discussed OSK/OSKM’s potential—and why the silence on details likely means patent activity and rapid progress. ⸻ ⏱️ Chapters 00:00 – Cold open 00:07 – Want to be young, healthy, beautiful forever? 00:29 – The big idea: Old cells can produce young cells 00:43 – Example: 35-year-old couple → brand-new human 01:10 – The mechanism already exists in our biology 01:31 – What is aging? Not a clock—accumulated cellular damage 02:06 – Seven processes of aging (high-level overview) 02:36 – Good news: Aging processes can be mitigated/reversed (engineering challenge) 03:15 – Enter iPSC (induced pluripotent stem cells) 03:29 – Pluripotency = ability to become other cell types 03:39 – 2012 Nobel Prize (Shinya Yamanaka) 03:59 – Four transcription factors that reset cells 04:10 – Reverting mature cells to pluripotent state 04:24 – OSKM: four letters that may lead to immortality 04:32 – Reversing old cells to younger cells 04:45 – Partial reprogramming: renew without losing identity 05:08 – OSKM details: roles of Oct4, Sox2, Klf4, c-Myc 05:51 – What OSKM enables; why it matters 06:03 – Two more technologies we need 06:14 – AI for modeling complex biology safely 06:57 – Nanotech for precise, controllable delivery (beyond viral vectors) 07:41 – AI decides where/when/how much OSKM to deploy 08:16 – The three pillars: AI + Nanotech + OSKM 08:55 – Notes from a Madrid longevity event (progress & patents) 10:04 – Aging = epigenetic drift & methylation changes 10:22 – OSK subset can reset epigenetic clocks (partial reprogramming) 11:02 – Where we are now: animal → human trajectory 11:24 – Blind mice eye rejuvenation (~“+20 years” human-equivalent vision) 11:46 – Early human applications: heart/brain targets first 12:11 – Scaling potential as we map systems and mitigations 12:38 – Philosophy of immortality: two paths 13:00 – Path 1: perfect replication (hard due to replication errors) 13:47 – Path 2: evolution with upgrades (identity through continuity) 14:06 – Future: engineered organs, design “upgrades” (e.g., heart) 15:07 – Being okay with gradual genetic improvements 15:45 – Wrap-up & CTA 15:54 – Thanks & goodbye ⸻ 🔑 Key Takeaways • Aging ≠ clock: It’s mainly repairable damage at cellular/epigenetic levels. • iPSC & OSKM: Yamanaka factors can reset cells; OSK can rejuvenate while keeping identity. • AI + Nanotech: Needed to model complex biology and deliver edits precisely & safely. • Roadmap: From animal results (e.g., eye rejuvenation) toward targeted human therapies. ⸻ ⚠️ Note Educational content only. Not medical advice. ⸻ 📌 Hashtags #OSKM #iPSC #Yamanaka #Longevity #Aging #Epigenetics #PartialReprogramming #GeneTherapy #Nanotechnology #AI #StemCells #cMyc #Oct4 #Sox2 #Klf4 #HealthyAging #Biotech #Rejuvenation #LifeExtension #Madrid Link to Aubrey de Grey Author of the Seven causes of aging. https://en.wikipedia.org/wiki/Aubrey_... 🔥 Please subscribe for more videos like this!    / @dialectic   🌍 Get a copy of my Science fiction novel The Heir of Infinity. https://maxfiction.com 📲 Follow me on social media: • Twitter/X: @maxrobbins • LinkedIn: www.linkedin.com/in/maxrobbins ✅ Please post in the comments if you know amazing people in the field that I can talk to to expand on the topics of Nanotechnology, Biotechnology, Artificial Intelligence and investment or drop me a message in the comments. Thank you for taking the time and attention to watch my videos!