Protein Folding Landscapes in the Living Cell скачать в хорошем качестве

Protein Folding Landscapes in the Living Cell

In this Perspective, we highlight studies of protein structure, stability, and folding kinetics that can now be carried out in prokaryotic and eukaryotic cells. The general features of cooperative folding transitions and kinetics remain the same as those in vitro, but the folding free-energy landscape and local viscosity vary according to microenvironments in the cellular landscape. Experiments in vitro provide a basis for comparing crowding and chemical effects with experiments inside of the cell. Perhaps cells even evolved to post-translationally modulate protein folding and binding through chemical patterns or by crowding. Subscribe! http://bit.ly/AmerChemSOc Facebook!   / journalofphysicalchemistry   Twitter!   / jphyschem   For more information, please visit the Journal of Physical Chemistry Letters website: https://pubs.acs.org/journal/jpclcd You might also like: ACS Energy Letters Perspectives & Reviews:    • Molecular Layer Deposition for Energy Conv...   ACS Nanotation:    • High-Efficiency Fog Collector: Water Unidi...   Publishing Your Research 101 Series:    • PYR101: George Whitesides - How to Write a...   Produced by the American Chemical Society, the world’s largest scientific society. ACS is a global leader in providing access to chemistry-related information and research through its multiple databases, peer-reviewed journals and scientific conferences. Join the American Chemical Society! https://bit.ly/Join_ACS