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Anticancer Drugs Could Enhance Potency of Some Immunotherapies

#anticancerdrugs #immunotherapies #cancercell An emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some cancer immunotherapies, according to a preclinical study led by Weill Cornell Medicine lymphoma researchers. The inhibitors target the EZH2 enzyme, whose activity in tumor cells is now recognized as a significant factor in many cancers. The study, published in Cancer Cell, found that EZH2 inhibition combined with T-cell based immunotherapy worked better at shrinking non-Hodgkin B-cell lymphomas than immunotherapy alone. This study proposed that inhibiting EZH2 might help enhance the potency and durability of these immunotherapies. EZH2 is an enzyme that normally helps program cell behavior by controlling the expression of specific genes. Mutations in the EZH2 gene, which makes the enzyme more active, are now recognized as common features of lymphomas, and inhibiting this enzyme has been found to benefit lymphoma patients even when they have non-mutant EZH2. Research by Dr. Béguelin and others has shown that EZH2 activity makes lymphoma cells less visible to the immune system, and generally helps create an immunosuppressive environment around lymphomas. EZH2 inhibition would reverse this immunosuppression, enhancing the activities of patients’ own anticancer T cells as well as T-cell immunotherapies. Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/c... 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/c... 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/c... Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter:   / medicaldialogs   Facebook:   / medicaldialogues   Instagram:   / medicaldialogues   LinkedIn:   / medical-dialogues   Website: https://medicaldialogues.in/