2. Pharmacodynamics: Enzyme Inhibition: General Pharmacology Lectures скачать в хорошем качестве

2. Pharmacodynamics: Enzyme Inhibition: General Pharmacology Lectures

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 :   / clinical.learning   Pharmacodynamics: Enzyme Inhibition - ------------------------------------------------------------------- Pharmacodynamics: Enzyme Inhibition 🧪💊 Enzyme inhibition is a crucial concept in pharmacodynamics, where drugs modulate enzyme activity to achieve therapeutic effects. Enzymes, acting as biological catalysts, are targeted by inhibitors to either reduce or completely block their action. This inhibition can be reversible or irreversible based on the nature of the interaction. Reversible Inhibition 🌀: These inhibitors bind non-covalently to the enzyme and can dissociate, restoring enzyme activity. They include competitive inhibitors, which compete with the substrate for the active site, and non-competitive inhibitors, which bind to an allosteric site, altering enzyme function without affecting substrate binding. Irreversible Inhibition 🚫: These inhibitors form a strong covalent bond with the enzyme, leading to permanent loss of enzymatic activity. An example is aspirin, which irreversibly inhibits cyclooxygenase (COX) enzymes, reducing inflammation and platelet aggregation. Key examples include: Statins 🩺: Competitive inhibitors of HMG-CoA reductase, used in hypercholesterolemia. Penicillin 🔬: Irreversibly inhibits bacterial transpeptidase, preventing cell wall synthesis. Proton Pump Inhibitors (PPIs) 🌡️: Irreversibly block H+/K+ ATPase in gastric parietal cells, reducing acid secretion. Enzyme inhibition has wide-ranging applications in treating infections, cancer, metabolic disorders, and more. Understanding the nuances of how inhibitors work allows for designing drugs with higher specificity and fewer side effects. 🌟✨ #Pharmacodynamics #EnzymeInhibition #MedicalEducation #MBBS #PharmaFacts #NEETPG #USMLE #BiochemistryExplained #MedicalStudents #LearnPharmacology