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The total combination of monocytes, mobile macrophages, fixed tissue macrophages, and a few specialized endothelial cells in the bone marrow, spleen, and lymph nodes is called the reticuloendothelial system. However, all or almost all these cells originate from monocytic stem cells; therefore, the reticuloendothelial system is almost synonymous with the monocyte-macrophage system. Because the term reticuloendothelial system is much better known in medical literature than the term monocyte-macrophage system, it should be remembered as a generalized phagocytic system located in all tissues, especially in those tissue areas where large quantities of particles, toxins, and other unwanted substances must be destroyed. Tissue Macrophages in the Skin and Subcutaneous Tissues (Histiocytes). Macrophages in the Lymph Nodes. Alveolar Macrophages in the Lungs. Macrophages (Kupffer Cells) in the Liver Sinusoids. Macrophages of the Spleen and Bone Marrow. Music: Walk Musician: @iksonmusic