Kelvin Tsoi, PhD: Combination Therapy, Monotherapy in Alzheimer Disease скачать в хорошем качестве

Kelvin Tsoi, PhD: Combination Therapy, Monotherapy in Alzheimer Disease

Read more: http://neurologylive.com/conferences/... At the 2018 Alzheimer’s Association International Conference in Chicago, Illinois, Kelvin Tsoi, PhD, The Chinese University of Hong Kong, sat down with NeurologyLive to discuss his study comparing the benefits of acetylcholinesterase inhibitors (AChEIs) plus memantine combination therapy to AChEIs or memantine alone in patients with mild-to-moderate Alzheimer disease. Tsoi and his team performed literature searches in MEDLINE, EMBASE, CINAHL, and EBM Reviews from Cochrane Centre from inception to August 2017, conducting a network meta-analysis of randomized controlled trials to compare the changes of assessment scales across medications by disease severity. Researchers identified a total of 23,707 patients with Alzheimer disease in 76 randomized trials in more than 30 countries. The trials that were selected evaluated AChEIs, memantine or the combination on 3 domains: cognitive function, activities of daily living and neuropsychiatric symptoms.